No Ifs or Bots. How Alcohol, 48,000 plates, and Stressed Forks Served Up Increased Mutation Rates

A Flame-Side Chat, with Dr Karin Voordeckers Recently, I described an article published by the group of Prof Kevin Verstrepen. Their work sought to investigate the molecular events that lead to enhanced mutation rates in the presence of Alcohol. I am pleased to report on a Flame-Side Chat with Karin Voordeckers, one of the team members who led …

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Brewing Beer In the Age of Infertility

It’s time to move past yeast’s fertility problems. Last week, an article by teams at the Manchester Institute of Biotechnology, the Department of Genetics & Genome Biology at the University of Leicester, and the Department of Chemical Engineering and Biotechnology at the University of Cambridge, was submitted to bioRxiv. This submission (which probably will be peer-reviewed soon) deals with the genetics of yeast. Subscribe now …

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Repeated Yeast Domestication Ups Beer Brewing Another Level

A Flame-Side Chat, with Dr Francisco Cubillos Riffo Last week, I wrote about an article by Dr Francisco Cubillos Riffo. Francisco is an Associate Researcher at The Millennium Institute for Integrative Biology (iBio). You can learn more about his research here by visiting the Molecular Genetics Lab Website. In short, his group investigates the diversity and genetics of yeasts in brewing. His …

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Yeast Domestication 2.0

Repeated growth and selection of genetically diverse populations re-domesticates brew yeast Growth, selection, growth and more selection. This virtuous cycle of trait-guided promotion of elite plants, animals or microbes underpins the domesticated landscape that surrounds us all. We all know that when it comes to brewing yeasts, repeated use and selection of best isolates, have …

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Craft Brewers’ Commercial Yeast Choice May Affect Beer Diversity

Pushing past yeast convention could boost craft beer flavour and adoption In this instalment of The Beerologist, I will describe a scientific paper by Prof. Dr Diego Bonatto that I recently found on bioRxiv (https://www.biorxiv.org/content/10.1101/2020.07.17.209171v2). The manuscript has been peer-reviewed and is now published here. The average price of a six-pack of (US) craft beer …

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Genetics of malting quality: The end of the road for crop improvement?

‘Au contraire’ my friends! In this instalment of the Beerologist, we will look into some of the latest research on Malts or Barley to be more precise. In the last episode of my newsletter, I stated how breeders need to breed malting barley varieties that have to fulfil strict criteria. To breed crop cultivars, geneticists …

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Micro-Mashing: A New Technology that Will Accelerate Beer Recipe Design

Micro-scale mashing to dissect beer biochemistry aided by statistical power Brewing beer is an exercise in experimentation. You (brewers) tinker with recipes more often than not, try new ingredients and combinations to create the best wort. Mashing is an integral part of the design process.  In a nutshell, mashing describes the process in which grains …

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